ea0099oc5.5 | Oral Communications 5: Pituitary and Neuroendocrinology | Part I | ECE2024
De Alcubierre Dario
, Gkasdaris Grigorios
, Briet Claire
, Almairac Fabien
, Boetto Julien
, Mouly Celine
, Larrieu-Ciron Delphine
, Joncour Anthony
, Mordrel Margaux
, Vasiljevic Alexandre
, Villa Chiara
, Sergeant Camille
, Ducray Francois
, Feuvret Loic
, Baussart Bertrand
, Raverot Gerald
, Jouanneau Emmanuel
Background: Papillary craniopharyngiomas (PCPs) are driven by V600E BRAF mutations in 95% of cases. Recently, combined anti-BRAF/MEK targeted therapy (TT) has emerged as a potential treatment in aggressive PCPs. However, standardized data on large cohorts are still lacking. Our study aimed to assess the real-life efficacy and safety of TT in patients with PCPs.Methods: This was a retrospective national multicenter study involving patients with V600E BRAF...